The show takes place from 1944 to 2002 and follows the lives of three families: the Crawfords, who seek to cover up the Roswell crash and the existence of aliens; the Keys, who are subject to frequent experimentation by the aliens; and the Clarkes, who sheltered one of the surviving aliens from the crash.

• Dakota Fanning
• Matt Frewer
• Emily Bergl
• Rei Hance
• Joel Gretsch
• Adam Kaufman
• John Hawkes
• Ryan Hurst