Boston detective Jane Rizzoli and medical examiner Dr. Maura Isles have each other's backs as they investigate their city’s grittiest and most puzzling homicides, from the Back Bay to back alleys. Some best friends shop together, some meet for Mojitos, some join book clubs. Rizzoli and Isles bust crime.

• Angie Harmon
• Sasha Alexander
• Jordan Bridges
• Bruce McGill
• Lorraine Bracco
• Idara Victor
• Adam Sinclair