Season two has several changes to Don's FBI team: Terry Lake is reassigned to Washington and two new members join Don and David Sinclair: Megan Reeves and Colby Granger. Charlie is challenged on one of his long-standing mathematical workpieces and starts work on a new theory, cognitive emergence theory.

• Rob Morrow
• David Krumholtz
• Judd Hirsch
• Alimi Ballard
• Peter MacNicol
• Navi Rawat
• Aya Sumika
• Sophina Brown