Dr. William Masters and Virginia Johnson struggle to get their work back on track while taking their relationship to a much more intimate place. Libby flounders in a loveless marriage and turns to volunteering. Former prostitute Betty DiMello tries for the American dream and ends up working with Masters and Johnson. Dr. Austin Langham becomes the spokesman for a popular diet company and the boy toy to its aggressive founder.

• Michael Sheen
• Lizzy Caplan
• Caitlin FitzGerald
• Annaleigh Ashford